Chun-Li Su’s research interests have centered around the anti-cancer mechanisms of naturally occurring components derived from plants. Using transcriptomic data and novel gene screening platforms, she not only determined that polyphenol curcumin enhances chemosensitivity by repressing a novel target of oncogenic Aurora-A and suppresses a transcription factor NF-ĸB by inhibiting CD4-T-cell-receptor-signaling, but also revealed that a novel arylnaphthalide lignan justicidin A acts as an autophagy inducer and inflammation suppressor. In precision nutrition, polyphenol phytoalexin pterostilbene was discovered to preferentially sensitize cisplatin-resistant bladder cancer with undruggable oncogenic HRAS, and a novel diosgenin saponin formosanin C was demonstrated to be a potent ferroptosis inducer against hepatocellular carcinoma with a higher NCOA4 expression via ferritinophagy. By conducting an integrated analysis of differentially expressed genes and pathways using a database of patients, ferroptosis was identified as a targetable metabolic niche in triple-negative breast cancer, and triple-negative breast cancer was shown to be vulnerable to formosanin C-induced ferroptosis. Nevertheless, antipsychotic thioridazine and antibiotic antimycin A were successfully repurposed to overcome the drug resistance of cancer stem cells in glioblastoma and non-small cell lung cancer, respectively. More recently, using in silico analysis and biochemical validations, an herbal medicine Virofree was found to target viral entry and replication of SARS-CoV-2, especially against Delta and Omicron variants, and to prevent ferroptosis, cytokine storm, acute respiratory distress syndrome, and pulmonary fibrosis, alleviating complications of COVID-19. Quantitative proteomics and gene ontology enrichment analysis were performed, which revealed that suboptimal folic acid exposure rewired oncogenic metabolism and proteomics signatures to promote breast cancer progression. These findings opened new avenues of research in nutritional biochemistry, and the novel gene expression screening platforms provided a short-cut to successfully predict possible mechanisms of naturally occurring components and to identify strategies capable of overcoming drug resistance by shedding light on the interrelationships among small molecules, genes, and disease in precision nutrition.